PDBe 3v6m

X-ray diffraction
2.69Å resolution

Inhibition of caspase-6 activity by single mutation outside the active site

Released:

Function and Biology Details

Reaction catalysed:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase-6 Chains: A, B, C, D, F, G, I, J
Molecule details ›
Chains: A, B, C, D, F, G, I, J
Length: 279 amino acids
Theoretical weight: 32.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55212 (Residues: 24-293; Coverage: 92%)
Gene names: CASP6, MCH2
Sequence domains: Caspase domain
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 81.146Å b: 162.63Å c: 89.15Å
α: 90° β: 95.01° γ: 90°
R-values:
R R work R free
0.217 0.215 0.259
Expression system: Escherichia coli