PDBe 3v6b

X-ray diffraction
3.2Å resolution

VEGFR-2/VEGF-E complex structure


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Vascular endothelial growth factor homolog Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.5 KDa
Source organism: Orf virus
Expression system: Komagataella pastoris
  • Canonical: P52584 (Residues: 21-133; Coverage: 100%)
Gene name: A2R
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines
Vascular endothelial growth factor receptor 2 Chain: R
Molecule details ›
Chain: R
Length: 424 amino acids
Theoretical weight: 47.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P6522
Unit cell:
a: 79.879Å b: 79.879Å c: 340.044Å
α: 90° β: 90° γ: 120°
R R work R free
0.239 0.237 0.276
Expression systems:
  • Komagataella pastoris
  • Spodoptera frugiperda