PDBe 3uvl

X-ray diffraction
2.2Å resolution

Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 21-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Histone-lysine N-methyltransferase 2C Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8NEZ4 (Residues: 4707-4717; Coverage: 0%)
Gene names: HALR, KIAA1506, KMT2C, MLL3

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21212
Unit cell:
a: 80.98Å b: 86.221Å c: 40.483Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.22
Expression systems:
  • Escherichia coli
  • Not provided