PDBe 3urf

X-ray diffraction
2.7Å resolution

Human RANKL/OPG complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 11, soluble form Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14788 (Residues: 162-317; Coverage: 49%)
Gene names: OPGL, RANKL, TNFSF11, TRANCE
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 11B Chain: Z
Molecule details ›
Chain: Z
Length: 171 amino acids
Theoretical weight: 19.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00300 (Residues: 22-186; Coverage: 43%)
Gene names: OCIF, OPG, TNFRSF11B
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P4132
Unit cell:
a: 144.8Å b: 144.8Å c: 144.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.251
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda