PDBe 3un0

X-ray diffraction
2.3Å resolution

Crystal Structure of MDC1 FHA Domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of DNA damage checkpoint protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 115 amino acids
Theoretical weight: 12.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q14676 (Residues: 26-138; Coverage: 5%)
Gene names: KIAA0170, MDC1, NFBD1
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 35.25Å b: 54.711Å c: 98.063Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.261
Expression system: Escherichia coli BL21