PDBe 3umh

X-ray diffraction
2Å resolution

X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Soluble APP-beta Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 25.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P05067 (Residues: 370-575; Coverage: 27%)
Gene names: A4, AD1, APP
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P43
Unit cell:
a: 39.692Å b: 39.692Å c: 126.215Å
α: 90° β: 90° γ: 90°
R R work R free
0.21 0.198 0.24
Expression system: Escherichia coli