PDBe 3u9w

X-ray diffraction
1.25Å resolution

Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A

Released:
Source organism: Homo sapiens
Entry authors: Niegowski D, Thunnissen M, Tholander F, Rinaldo-Matthis A, Muroya A, Haeggstrom JZ

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene A-4 hydrolase Chain: A
Molecule details ›
Chain: A
Length: 608 amino acids
Theoretical weight: 69.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09960 (Residues: 4-611; Coverage: 100%)
Gene names: LTA4, LTA4H
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P212121
Unit cell:
a: 78.078Å b: 86.799Å c: 99.145Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.134 0.134 0.161
Expression system: Escherichia coli