PDBe 3u69

X-ray diffraction
1.55Å resolution

Unliganded wild-type human thrombin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 30 amino acids
Theoretical weight: 3.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 334-363; Coverage: 5%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 57.555Å b: 72.995Å c: 83.042Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.135 0.133 0.167