PDBe 3tx7

X-ray diffraction
2.76Å resolution

Crystal structure of LRH-1/beta-catenin complex

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis of coactivation of liver receptor homolog-1 by β-catenin.
Proc. Natl. Acad. Sci. U.S.A. 109 143-8 (2012)
PMID: 22187462

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin beta-1 Chain: A
Molecule details ›
Chain: A
Length: 527 amino acids
Theoretical weight: 57.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35222 (Residues: 138-663; Coverage: 67%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Nuclear receptor subfamily 5 group A member 2 Chain: B
Molecule details ›
Chain: B
Length: 352 amino acids
Theoretical weight: 40.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00482 (Residues: 191-541; Coverage: 65%)
Gene names: B1F, CPF, FTF, NR5A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 49.824Å b: 151.602Å c: 76.131Å
α: 90° β: 96.96° γ: 90°
R-values:
R R work R free
0.201 0.199 0.243
Expression system: Escherichia coli