PDBe 3twq

X-ray diffraction
2.15Å resolution

Crystal structure of ARC4 from human Tankyrase 2 (apo form)

Released:

Function and Biology Details

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase tankyrase-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 175 amino acids
Theoretical weight: 18.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H2K2 (Residues: 484-655; Coverage: 15%)
Gene names: PARP5B, TANK2, TNKL, TNKS2
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P3112
Unit cell:
a: 47.524Å b: 47.524Å c: 250.935Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.174 0.234
Expression system: Escherichia coli BL21(DE3)