PDBe 3tuc

X-ray diffraction
2.1Å resolution

Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase SYK Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P43405 (Residues: 343-635; Coverage: 46%)
Gene name: SYK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 48Å b: 69.47Å c: 83.61Å
α: 90° β: 90° γ: 90°
R R work R free
0.216 0.213 0.285
Expression system: Not provided