PDBe 3tje

X-ray diffraction
1.93Å resolution

Crystal structure of Fas receptor extracellular domain in complex with Fab E09

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab E09, light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fab E09, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 245 amino acids
Theoretical weight: 25.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Tumor necrosis factor receptor superfamily member 6 Chain: F
Molecule details ›
Chain: F
Length: 156 amino acids
Theoretical weight: 17.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25445 (Residues: 17-172; Coverage: 47%)
Gene names: APT1, FAS, FAS1, TNFRSF6
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 89.49Å b: 166.4Å c: 110.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.232
Expression systems:
  • Homo sapiens
  • Escherichia coli