› 3t8x

X-ray diffraction
1.9Å resolution

Crystal structure of human CD1b in complex with synthetic antigenic diacylsulfoglycolipid SGL12 and endogenous spacer

Released:
DOI: 10.2210/pdb3t8x/pdb
PDB entry 3t8x coloured by chain, front view.
PDB entry 3t8x coloured by chain, side view.
PDB entry 3t8x coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Garcia-Alles LF, Maveyraud L, Mourey L, Julien S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151323 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
T-cell surface glycoprotein CD1b Chains: A, C
Molecule details ›
Chains: A, C
Length: 301 amino acids
Theoretical weight: 33.48 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P29016 (Residues: 19-298; Coverage: 89%)
Gene name: CD1B
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, D
Molecule details ›
Chains: B, D
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
5 bound ligands:
Ligand SO4 5 x SO4
Ligand ACT 1 x ACT
Ligand T8X 2 x T8X
Ligand ULI 2 x ULI
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 203.25Å b: 67.58Å c: 88.19Å
α: 90° β: 112.26° γ: 90°
R-values:
R R work R free
0.167 0.165 0.211
Expression system: Mus musculus

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