PDBe 3t3z

X-ray diffraction
2.35Å resolution

Human Cytochrome P450 2E1 in complex with pilocarpine


Function and Biology Details

Reaction catalysed:
4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Cytochrome P450 2E1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 476 amino acids
Theoretical weight: 55.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P05181 (Residues: 32-493; Coverage: 94%)
Gene names: CYP2E, CYP2E1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome p450

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P41
Unit cell:
a: 100.638Å b: 100.638Å c: 259.453Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.217 0.281
Expression system: Escherichia coli