PDBe 3sw2

X-ray diffraction
2.42Å resolution

X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor X light chain Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.21 KDa
Source organism: Homo sapiens
  • Canonical: P00742 (Residues: 85-178; Coverage: 21%)
Gene name: F10
Sequence domains:
Structure domains: Laminin
Activated factor Xa heavy chain Chain: B
Molecule details ›
Chain: B
Length: 238 amino acids
Theoretical weight: 26.87 KDa
Source organism: Homo sapiens
  • Canonical: P00742 (Residues: 235-472; Coverage: 52%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P212121
Unit cell:
a: 57.018Å b: 72.515Å c: 77.956Å
α: 90° β: 90° γ: 90°
R R work R free
0.199 0.193 0.262