PDBe 3srf

X-ray diffraction
2.84Å resolution

Human M1 pyruvate kinase

Released:
Source organism: Homo sapiens
Entry authors: Morgan HP, O'Reilly F, Palmer R, McNae IW, Nowicki MW, Wear MA, Fothergill-Gilmore LA, Walkinshaw MD

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate kinase PKM Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 551 amino acids
Theoretical weight: 60.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14618 (Residues: 1-531; Coverage: 100%)
  • Best match: P14618-2 (Residues: 1-531)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 238.003Å b: 192.222Å c: 109.06Å
α: 90° β: 89.999° γ: 90°
R-values:
R R work R free
0.224 0.221 0.28
Expression system: Escherichia coli