PDBe 3sm9

X-ray diffraction
2.26Å resolution

Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist

Source organism: Homo sapiens
Entry authors: Wernimont AK, Dong A, Seitova A, Crombet L, Khutoreskaya G, Edwards AM, Arrowsmith CH, Bountra C, Weigelt J, Cossar D, Dobrovetsky E, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Metabotropic glutamate receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 479 amino acids
Theoretical weight: 54.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q14832 (Residues: 26-504; Coverage: 56%)
Gene names: GPRC1C, GRM3, MGLUR3
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: I222
Unit cell:
a: 83.402Å b: 98.633Å c: 203.513Å
α: 90° β: 90° γ: 90°
R R work R free
0.202 0.201 0.227
Expression system: Spodoptera frugiperda