PDBe 3sko

X-ray diffraction
1.6Å resolution

Crystal structure of the HLA-B8-A66-FLR, mutant A66 of the HLA B8

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B-8 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30460 (Residues: 25-301; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Epstein-Barr nuclear antigen 3 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: Human gammaherpesvirus 4
Expression system: Not provided
UniProt:
  • Canonical: Q3KST2 (Residues: 325-333; Coverage: 1%)
Gene names: BLRF3-BERF1, EBNA3

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 50.9Å b: 81.85Å c: 110.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.234
Expression systems:
  • Escherichia coli
  • Not provided