PDBe 3se3

X-ray diffraction
4Å resolution

human IFNa2-IFNAR ternary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interferon alpha/beta receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 414 amino acids
Theoretical weight: 47.63 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P17181 (Residues: 28-436; Coverage: 77%)
Gene names: IFNAR, IFNAR1
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins
Interferon alpha-2 Chain: B
Molecule details ›
Chain: B
Length: 166 amino acids
Theoretical weight: 19.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01563 (Residues: 24-188; Coverage: 100%)
Gene names: IFNA2, IFNA2A, IFNA2B, IFNA2C
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;
Interferon alpha/beta receptor 2 Chain: C
Molecule details ›
Chain: C
Length: 199 amino acids
Theoretical weight: 22.89 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P48551 (Residues: 34-232; Coverage: 41%)
Gene names: IFNABR, IFNAR2, IFNARB
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6122
Unit cell:
a: 93.37Å b: 93.37Å c: 401.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.251 0.311
Expression systems:
  • Trichoplusia ni
  • Escherichia coli