PDBe 3rvg

X-ray diffraction
2.5Å resolution

Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 35.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 835-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P65
Unit cell:
a: 124.433Å b: 124.433Å c: 36.734Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.221 0.3
Expression system: Spodoptera frugiperda