PDBe 3r3i

X-ray diffraction
3.57Å resolution

Crystal Structure of C-terminal truncation of UDP-glucose Pyrophosphorylase of Homo sapiens

Released:
Source organism: Homo sapiens
Entry authors: Zheng X, Yu Q

Function and Biology Details

Reaction catalysed:
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UTP--glucose-1-phosphate uridylyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 528 amino acids
Theoretical weight: 59.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16851 (Residues: 1-508; Coverage: 100%)
Gene names: UGP1, UGP2
Sequence domains: UTP--glucose-1-phosphate uridylyltransferase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 140.266Å b: 140.266Å c: 315.284Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.235 0.233 0.286
Expression system: Escherichia coli BL21(DE3)