PDBe 3r3g

X-ray diffraction
1.75Å resolution

Structure of human thrombin with residues 145-150 of murine thrombin.

Released:
Source organism: Homo sapiens
Primary publication:
Rigidification of the autolysis loop enhances Na(+) binding to thrombin.
Biophys. Chem. 159 6-13 (2011)
PMID: 21536369

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombin light chain Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.65 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P00734 (Residues: 333-363; Coverage: 5%)
Gene name: F2
Thrombin heavy chain Chain: B
Molecule details ›
Chain: B
Length: 259 amino acids
Theoretical weight: 29.97 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: C2
Unit cell:
a: 116.072Å b: 48.058Å c: 53.722Å
α: 90° β: 92.08° γ: 90°
R-values:
R R work R free
0.186 0.184 0.222
Expression system: Mus musculus