PDBe 3qzv

X-ray diffraction
2Å resolution

Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nucleosome-remodeling factor subunit BPTF Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 20.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12830 (Residues: 2865-3033; Coverage: 6%)
Gene names: BPTF, FAC1, FALZ
Sequence domains:
Structure domains:
Histone H4 Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.07 KDa
Source organism: Xenopus laevis
Expression system: Not provided
UniProt:
  • Canonical: P62805 (Residues: 8-18; Coverage: 11%)
Gene names: H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 65.525Å b: 38.513Å c: 87.752Å
α: 90° β: 111.2° γ: 90°
R-values:
R R work R free
0.186 0.182 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided