PDBe 3qzs

X-ray diffraction
1.8Å resolution

Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nucleosome-remodeling factor subunit BPTF Chains: A, B
Molecule details ›
Chains: A, B
Length: 115 amino acids
Theoretical weight: 13.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW Q12830 (Residues: 2924-3033; Coverage: 4%)
Gene names: BPTF, FAC1, FALZ
Sequence domains: Bromodomain
Structure domains: Bromodomain-like
Histone H4 Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.18 KDa
Source organism: Xenopus laevis
Expression system: Not provided
UniProt:
  • Canonical: NEW P62805 (Residues: 13-22; Coverage: 10%)
Gene names: H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 45.739Å b: 27.197Å c: 84.198Å
α: 90° β: 89.87° γ: 90°
R-values:
R R work R free
0.178 0.173 0.23
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided