PDBe 3qwq

X-ray diffraction
2.75Å resolution

Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 648 amino acids
Theoretical weight: 71.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P00533 (Residues: 1-642; Coverage: 52%)
  • Best match: P00533-4 (Residues: 1-627)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Structure domains:
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 12.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 68Å b: 72.1Å c: 262Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.202 0.246
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli