PDBe 3qnw

X-ray diffraction
2.65Å resolution

Caspase-6 in complex with Z-VAD-FMK inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero nonamer
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Caspase-6 subunit p18 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 156 amino acids
Theoretical weight: 18.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55212 (Residues: 24-179; Coverage: 53%)
Gene names: CASP6, MCH2
Structure domains: Rossmann fold
Caspase-6 subunit p11 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 100 amino acids
Theoretical weight: 11.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55212 (Residues: 194-293; Coverage: 34%)
Gene names: CASP6, MCH2
Structure domains: Caspase-like
Z-VAD-FMK Chains: X, Y, Z
Molecule details ›
Chains: X, Y, Z
Length: 5 amino acids
Theoretical weight: 472 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 87.206Å b: 65.446Å c: 91.718Å
α: 90° β: 91.24° γ: 90°
R-values:
R R work R free
0.243 0.24 0.287
Expression systems:
  • Escherichia coli
  • Not provided