PDBe 3qic

X-ray diffraction
2.2Å resolution

The structure of human glucokinase E339K mutation

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucokinase Chain: A
Molecule details ›
Chain: A
Length: 470 amino acids
Theoretical weight: 53.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 12-465; Coverage: 98%)
Gene name: GCK
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 80.74Å b: 80.74Å c: 178.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.213 0.25
Expression system: Escherichia coli