PDBe 3qhe

X-ray diffraction
2.4Å resolution

Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli and the tyrosine-rich domain of Sam68

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adenomatous polyposis coli protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 337 amino acids
Theoretical weight: 37.5 KDa
Source organism: Homo sapiens
Expression system: cell free synthsis
UniProt:
  • Canonical: P25054 (Residues: 396-732; Coverage: 12%)
Gene names: APC, DP2.5
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
KH domain-containing, RNA-binding, signal transduction-associated protein 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 55 amino acids
Theoretical weight: 6.49 KDa
Source organism: Homo sapiens
Expression system: cell free synthsis
UniProt:
  • Canonical: Q07666 (Residues: 365-419; Coverage: 12%)
Gene names: KHDRBS1, SAM68
Sequence domains: Tyrosine-rich domain of Sam68

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P61
Unit cell:
a: 148.223Å b: 148.223Å c: 63.379Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.23
Expression system: cell free synthsis