PDBe 3qfb

X-ray diffraction
2.6Å resolution

Crystal structure of the human thioredoxin reductase-thioredoxin complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thioredoxin reductase 1, cytoplasmic Chains: A, B
Molecule details ›
Chains: A, B
Length: 519 amino acids
Theoretical weight: 56.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16881 (Residues: 151-649; Coverage: 77%)
  • Best match: Q16881-5 (Residues: 1-499)
Gene names: GRIM12, KDRF, TXNRD1
Sequence domains:
Structure domains: Enolase-like; domain 1
Thioredoxin Chains: C, D
Molecule details ›
Chains: C, D
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10599 (Residues: 2-105; Coverage: 99%)
Gene names: TRDX, TRX, TRX1, TXN
Sequence domains: Thioredoxin

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 71.27Å b: 121.7Å c: 73.89Å
α: 90° β: 95.33° γ: 90°
R-values:
R R work R free
0.235 0.235 0.297
Expression system: Escherichia coli