PDBe 3qby

X-ray diffraction
1.95Å resolution

Crystal structure of the PWWP domain of human Hepatoma-derived growth factor 2

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hepatoma-derived growth factor-related protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 94 amino acids
Theoretical weight: 10.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW Q7Z4V5 (Residues: 1-93; Coverage: 14%)
Gene names: HDGF2, HDGFL2, HDGFRP2, HRP2, UNQ785/PRO1604
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.
Histone H4 Chain: H
Molecule details ›
Chain: H
Length: 11 amino acids
Theoretical weight: 1.44 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: NEW P62805 (Residues: 16-26; Coverage: 11%)
Gene names: H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 41.527Å b: 41.681Å c: 156.749Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.253
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided