› 3py7

X-ray diffraction
2.29Å resolution

Crystal structure of full-length Bovine Papillomavirus oncoprotein E6 in complex with LD1 motif of paxillin at 2.3A resolution

Released:
DOI: 10.2210/pdb3py7/pdb
PDB entry 3py7 coloured by chain, front view.
PDB entry 3py7 coloured by chain, side view.
PDB entry 3py7 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.
Zanier K, Charbonnier S, Sidi AO, McEwen AG, Ferrario MG, Poussin-Courmontagne P, Cura V, Brimer N, Babah KO, Ansari T, Muller I, Stote RH, Cavarelli J, Vande Pol S, Travé G
Science 339 694-8 (2013)
PMID: 23393263

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139304 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Maltose/maltodextrin-binding periplasmic protein; Protein E6 Chain: A
Molecule details ›
Chain: A
Length: 523 amino acids
Theoretical weight: 57.75 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: P06931 (Residues: 1-137; Coverage: 100%)
Gene names: E6, JW3994, b4034, malE
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2221
Unit cell:
a: 105.051Å b: 123.09Å c: 94.594Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.225
Expression system: Escherichia coli

Quick links

Citations

32 review citations

The human papillomavirus family and its role in carcinogenesis.
Tommasino M. (2014)
31 more

5 mentions without citation

Crystal structures of MBP fusion proteins.
Waugh DS. (2016)
4 more