› 3pxk

X-ray diffraction
1.79Å resolution

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH Pyrrolo[2,3-d]thiazole

Released:
DOI: 10.2210/pdb3pxk/pdb
PDB entry 3pxk coloured by chain, front view.
PDB entry 3pxk coloured by chain, side view.
PDB entry 3pxk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Koolman H, Heinrich T, Musil D

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 282 amino acids
Theoretical weight: 32.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05397 (Residues: 410-689; Coverage: 27%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PXK 2 x PXK
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 45.431Å b: 50.873Å c: 66.894Å
α: 98.16° β: 101.98° γ: 93.54°
R-values:
R R work R free
0.185 0.184 0.216
Expression system: Spodoptera frugiperda

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