PDBe 3pkj

X-ray diffraction
2.12Å resolution

Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose

Released:
Source organism: Homo sapiens
Primary publication:
Structure and biochemical functions of SIRT6.
J. Biol. Chem. 286 14575-87 (2011)
PMID: 21362626

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacetylase sirtuin-6 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 355 amino acids
Theoretical weight: 39.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N6T7 (Residues: 2-355; Coverage: 100%)
Gene names: SIR2L6, SIRT6
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 89.042Å b: 135.78Å c: 89.105Å
α: 90° β: 120.02° γ: 90°
R-values:
R R work R free
0.236 0.234 0.264
Expression system: Escherichia coli