PDBe 3pki

X-ray diffraction
2.04Å resolution

Human SIRT6 crystal structure in complex with ADP ribose

Released:
Source organism: Homo sapiens
Primary publication:
Structure and biochemical functions of SIRT6.
J. Biol. Chem. 286 14575-87 (2011)
PMID: 21362626

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacetylase sirtuin-6 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 355 amino acids
Theoretical weight: 39.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N6T7 (Residues: 2-355; Coverage: 100%)
Gene names: SIR2L6, SIRT6
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 77.367Å b: 90.2Å c: 90.18Å
α: 118.09° β: 91.39° γ: 115.8°
R-values:
R R work R free
0.184 0.183 0.213
Expression system: Escherichia coli