PDBe 3p7z

X-ray diffraction
2.65Å resolution

Crystal structure of the Neurofibromin Sec14-PH module containing the patient derived mutation I1584V

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurofibromin Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21359 (Residues: 1566-1837; Coverage: 10%)
Gene name: NF1
Sequence domains: Divergent CRAL/TRIO domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P41212
Unit cell:
a: 113.061Å b: 113.061Å c: 124.612Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.266
Expression system: Escherichia coli