PDBe 3p2x

X-ray diffraction
2Å resolution

Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity

Released:
Source organism: Homo sapiens
Entry authors: Hua QX, Wan ZL, Huang K, Hu SQ, Phillip NF, Jia WH, Whittingham J, Dodson GG, Katsoyannis PG, Weiss MA

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.45 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: R3
Unit cell:
a: 78.363Å b: 78.363Å c: 36.848Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.229 0.314
Expression system: Not provided