PDBe 3ozl

X-ray diffraction
1.9Å resolution

Crystal structure of human transthyretin variant A25T in complex with flufenamic acid.

Released:
Source organism: Homo sapiens
Entry authors: Lima LMTR, Palmieri LC, Foguel D, Palhano FL

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P21212
Unit cell:
a: 43.93Å b: 85.607Å c: 65.228Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.247
Expression system: Escherichia coli