PDBe 3ovj

X-ray diffraction
1.8Å resolution

Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G

Released:
Source organism: synthetic construct
Primary publication:
Towards a pharmacophore for amyloid.
OpenAccess logo PLoS Biol. 9 e1001080 (2011)
PMID: 21695112

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 amino acids
Theoretical weight: 725 Da
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: NEW P05067 (Residues: 687-692; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 9.536Å b: 26.008Å c: 25.803Å
α: 62.28° β: 88.59° γ: 88.45°
R-values:
R R work R free
0.207 0.205 0.22
Expression system: Not provided