PDBe 3oad

X-ray diffraction
2.17Å resolution

Design and optimization of new piperidines as renin inhibitors

Released:

Function and Biology Details

Reaction catalysed:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Renin Chains: A, C
Molecule details ›
Chains: A, C
Length: 166 amino acids
Theoretical weight: 18.23 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00797 (Residues: 67-232; Coverage: 43%)
Gene name: REN
Structure domains: Acid Proteases
Renin Chains: B, D
Molecule details ›
Chains: B, D
Length: 176 amino acids
Theoretical weight: 19.43 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00797 (Residues: 237-406; Coverage: 44%)
Gene name: REN
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 66.666Å b: 93.405Å c: 118.271Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.213 0.291
Expression system: Cricetulus griseus