PDBe 3o8e

X-ray diffraction
2.84Å resolution

Structure of extracelllar portion of CD46 in complex with Adenovirus type 11 knob


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fiber 36.1 kDa protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 213 amino acids
Theoretical weight: 23.75 KDa
Source organism: Human adenovirus 11
Expression system: Escherichia coli
  • Canonical: Q772X2 (Residues: 117-325; Coverage: 64%)
Sequence domains: Adenoviral fibre protein (knob domain)
Structure domains: Adenovirus pIV-related, attachment domain
Membrane cofactor protein Chains: B, D
Molecule details ›
Chains: B, D
Length: 252 amino acids
Theoretical weight: 28.46 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P15529 (Residues: 35-286; Coverage: 70%)
Gene names: CD46, MCP, MIC10
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P63
Unit cell:
a: 108.16Å b: 108.16Å c: 222.99Å
α: 90° β: 90° γ: 120°
R R work R free
0.21 0.21 0.229
Expression systems:
  • Escherichia coli
  • Cricetulus griseus