PDBe 3o2x

X-ray diffraction
1.9Å resolution

MMP-13 in complex with selective tetrazole core inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Kiefer JR, Barta TE, Becker DP, Mathis KJ, Williams J

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 164 amino acids
Theoretical weight: 18.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 105-267; Coverage: 36%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 73.864Å b: 95.257Å c: 120.076Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.21
Expression system: Escherichia coli