PDBe 3o2g

X-ray diffraction
1.78Å resolution

Crystal Structure of Human gamma-butyrobetaine,2-oxoglutarate dioxygenase 1 (BBOX1)

Released:
Source organism: Homo sapiens
Entry authors: Krojer T, Kochan G, McDonough MA, von Delft F, Leung IKH, Henry L, Claridge TDW, Pilka E, Ugochukwu E, Muniz J, Filippakopoulos P, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Kavanagh KL, Schofield CJ, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO(2) 

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-butyrobetaine dioxygenase Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 44.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75936 (Residues: 1-387; Coverage: 100%)
Gene names: BBH, BBOX, BBOX1
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: R32
Unit cell:
a: 107.386Å b: 107.386Å c: 204.919Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.149 0.147 0.176
Expression system: Trichoplusia ni