› 3nyl

X-ray diffraction
2.8Å resolution

The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain

Released:
DOI: 10.2210/pdb3nyl/pdb
PDB entry 3nyl coloured by chain, front view.
PDB entry 3nyl coloured by chain, side view.
PDB entry 3nyl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Wang Y, Ha Y
Mol Cell 15 343-53 (2004)
PMID: 15304215

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble APP-beta Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 365-570; Coverage: 27%)
Gene names: A4, AD1, APP
Sequence domains: E2 domain of amyloid precursor protein
Structure domains: Amyloid precursor protein, E2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: I422
Unit cell:
a: 83.589Å b: 83.589Å c: 147.341Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.258 0.322
Expression system: Escherichia coli

Quick links

Citations

31 review citations

APP processing in Alzheimer's disease.
Zhang et al. (2011)
30 more

6 mentions without citation

Alzheimer's disease--a panorama glimpse.
Zhao et al. (2014)
5 more