PDBe 3njp

X-ray diffraction
3.3Å resolution

The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor Chains: C, D
Molecule details ›
Chains: C, D
Length: 47 amino acids
Theoretical weight: 5.56 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01133 (Residues: 975-1021; Coverage: 4%)
Gene name: EGF
Sequence domains: EGF-like domain
Structure domains: Laminin
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 614 amino acids
Theoretical weight: 67.99 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00533 (Residues: 25-638; Coverage: 52%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P3121
Unit cell:
a: 220.167Å b: 220.167Å c: 113.123Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.265 0.263 0.298
Expression system: Cricetulus griseus