PDBe 3nj4

X-ray diffraction
2.5Å resolution

Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Adenosylhomocysteinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 435 amino acids
Theoretical weight: 48.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P23526 (Residues: 1-432; Coverage: 100%)
Gene names: AHCY, SAHH
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand NAD 4 x NAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: P21
Unit cell:
a: 91.201Å b: 81.939Å c: 129.599Å
α: 90° β: 107.01° γ: 90°
R R work R free
0.209 0.207 0.261
Expression system: Escherichia coli