PDBe 3nfn

X-ray diffraction
2.39Å resolution

Recognition of peptide-MHC by a V-delta/V-beta TCR

Released:
Primary publication:
Plasticity of human CD8αα binding to peptide-HLA-A*2402.
Mol. Immunol. 48 2198-202 (2011)
PMID: 21645925

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A-24 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05534 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Protein Nef Chain: C
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 1.29 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q9YYU8 (Residues: 134-143; Coverage: 5%)
Gene name: nef

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2
Unit cell:
a: 161.735Å b: 65.062Å c: 50.415Å
α: 90° β: 90.23° γ: 90°
R-values:
R R work R free
0.19 0.188 0.222
Expression systems:
  • Escherichia coli
  • Not provided