PDBe 3mxy

X-ray diffraction
2.3Å resolution

Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C31 Chain: L
Molecule details ›
Chain: L
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 754-762; Coverage: 1%)
  • Best match: P05067-2 (Residues: 48-50)
Gene names: A4, AD1, APP
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 55-152; Coverage: 45%)
  • Best match: P62993-2 (Residues: 60-111)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P6122
Unit cell:
a: 58.98Å b: 58.98Å c: 117.06Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.232 0.252
Expression systems:
  • Not provided
  • Escherichia coli