PDBe 3mx0

X-ray diffraction
3.51Å resolution

Crystal Structure of EphA2 ectodomain in complex with ephrin-A5

Released:
Source organism: Homo sapiens
Primary publication:
Architecture of Eph receptor clusters.
Proc. Natl. Acad. Sci. U.S.A. 107 10860-5 (2010)
PMID: 20505120

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ephrin type-A receptor 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 409 amino acids
Theoretical weight: 45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P29317 (Residues: 27-435; Coverage: 43%)
Gene names: ECK, EPHA2
Sequence domains:
Structure domains: Immunoglobulins
Ephrin-A5 Chains: B, D
Molecule details ›
Chains: B, D
Length: 138 amino acids
Theoretical weight: 16.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P52803 (Residues: 28-165; Coverage: 66%)
Gene names: EFNA5, EPLG7, LERK7
Sequence domains: Ephrin
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 57.859Å b: 89.049Å c: 198.15Å
α: 90° β: 96.22° γ: 90°
R-values:
R R work R free
0.237 0.234 0.295
Expression system: Homo sapiens