PDBe 3mrm

X-ray diffraction
1.9Å resolution

Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1406-1415 decapeptide

Released:
Source organisms:
Entry authors: Gras S, Echasserieau K, Saulquin X, Bonneville M, Housset D

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A-2 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 34.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01892 (Residues: 25-300; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
10-meric peptide from Genome polyprotein Chain: P
Molecule details ›
Chain: P
Length: 10 amino acids
Theoretical weight: 998 Da
Source organism: Hepacivirus C
Expression system: Not provided
UniProt:
  • Canonical: Q9DIT6 (Residues: 1406-1415; Coverage: 0%)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 53.223Å b: 80.985Å c: 56.341Å
α: 90° β: 112.24° γ: 90°
R-values:
R R work R free
0.192 0.19 0.25
Expression systems:
  • Escherichia coli
  • Not provided