PDBe 3mos

X-ray diffraction
1.75Å resolution

The structure of human Transketolase

Released:

Function and Biology Details

Reaction catalysed:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transketolase Chain: A
Molecule details ›
Chain: A
Length: 616 amino acids
Theoretical weight: 67.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29401 (Residues: 3-618; Coverage: 99%)
Gene name: TKT
Sequence domains:

Ligands and Environments


Cofactor: Ligand TPP 1 x TPP
3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2
Unit cell:
a: 113.63Å b: 85.33Å c: 72.74Å
α: 90° β: 125.69° γ: 90°
R-values:
R R work R free
0.164 0.162 0.206
Expression system: Escherichia coli